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Article

Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia

18 Apr 2006

Abstract excerpt

Aberrant expression of 1 or more transcription factor oncogenes is a critical component of the molecular pathogenesis of human T-cell acute lymphoblastic leukemia (T-ALL); however, oncogenic transcriptional programs downstream of T-ALL oncogenes are mostly unknown. TAL1/SCL is a basic helix-loop-helix (bHLH) transcription factor oncogene aberrantly expressed in 60% of human T-ALLs. We used chromatin...

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PMID: 16621969
DOI: 10.1182/blood-2005-08-3482

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