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Article

TAL1 activation in T-cell acute lymphoblastic leukemia: a novel oncogenic 3' neo-enhancer.

Haematologica - 1 May 2023

Smith Charlotte, Goyal Ashish, Weichenhan Dieter, Allemand Eric, Mayakonda Anand, Toprak Umut, Riedel Anna, Balducci Estelle, Manojkumar Manisha, Pejkovska Anastasija, Mücke Oliver, Sollier Etienne, Bakr Ali, Breuer Kersten, Lutsik Pavlo, Hermine Olivier, Spicuglia Salvatore, Asnafi Vahid, Plass Christoph, Touzart Aurore

Abstract excerpt

T-cell acute lymphocytic leukemia protein 1 (TAL1) is one of the most frequently deregulated oncogenes in T-cell acute lymphoblastic leukemia (T-ALL). Its deregulation can occur through diverse cis-alterations, including SIL-TAL1 microdeletions, translocations with T-cell Receptor loci, and more recently described upstream intergenic non-coding mutations. These mutations consist of recurrent focal microinsertions...

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Identifiers

PMID: 36632736
DOI: 10.3324/haematol.2022.281583
PMCID: PMC10153542

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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