Article
Inactivation of LEF1 in T-cell acute lymphoblastic leukemia.
Blood - 8 Apr 2010
Gutierrez Alejandro, Sanda Takaomi, Ma Wenxue, Zhang Jianhua, Grebliunaite Ruta, Dahlberg Suzanne, Neuberg Donna, Protopopov Alexei, Winter Stuart S, Larson Richard S, Borowitz Michael J, Silverman Lewis B, Chin Lynda, Hunger Stephen P, Jamieson Catriona, Sallan Stephen E, Look A Thomas
Abstract excerpt
To further unravel the molecular pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL), we performed high-resolution array comparative genomic hybridization on diagnostic specimens from 47 children with T-ALL and identified monoallelic or biallelic LEF1 microdeletions in 11% (5 of 47) of these primary samples. An additional 7% (3 of 44) of the cases harbored nonsynonymous sequence alterations of LEF1, 2 of...
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