Article
Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null mice.
Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 2003
Amiry-Moghaddam Mahmood, Williamson Anne, Palomba Maria, Eid Tore, de Lanerolle Nihal C, Nagelhus Erlend A, Adams Marvin E, Froehner Stanley C, Agre Peter, Ottersen Ole P
Abstract excerpt
Recovery from neuronal activation requires rapid clearance of potassium ions (K+) and restoration of osmotic equilibrium. The predominant water channel protein in brain, aquaporin-4 (AQP4), is concentrated in the astrocyte end-feet membranes adjacent to blood vessels in neocortex and cerebellum by association with alpha-syntrophin protein. Although AQP4 has been implicated in the pathogenesis of brain edema, its...
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