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Article

Evaluation of gliovascular functions of AQP4 readthrough isoforms

23 Nov 2023

Abstract excerpt

Aquaporin-4 (AQP4) is a water channel protein that links the astrocytic endfeet to the blood-brain barrier (BBB) and regulates water and potassium homeostasis in the brain, as well as the glymphatic clearance of waste products that would otherwise potentiate neurological diseases. Recently, translational readthrough was shown to generate a C-terminally extended variant of AQP4, known as AQP4x, which...

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Identifiers

PMID: 38077948
DOI: 10.3389/fncel.2023.1272391

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