Article
The impact of alpha-syntrophin deletion on the changes in tissue structure and extracellular diffusion associated with cell swelling under physiological and pathological conditions.
PloS one - 1 Jan 2013
Dmytrenko Lesia, Cicanic Michal, Anderova Miroslava, Vorisek Ivan, Ottersen Ole Petter, Sykova Eva, Vargova Lydia
Abstract excerpt
Aquaporin-4 (AQP4) is the primary cellular water channel in the brain and is abundantly expressed by astrocytes along the blood-brain barrier and brain-cerebrospinal fluid interfaces. Water transport via AQP4 contributes to the activity-dependent volume changes of the extracellular space (ECS), which affect extracellular solute concentrations and neuronal excitability. AQP4 is anchored by α-syntrophin (α-syn),...
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