Article
New insights into water transport and edema in the central nervous system from phenotype analysis of aquaporin-4 null mice.
Neuroscience - 1 Jan 2004
Manley G T, Binder D K, Papadopoulos M C, Verkman A S
Abstract excerpt
Aquaporin-4 (AQP4) is the major water channel in the CNS. Its expression at fluid-tissue barriers (blood-brain and brain-cerebrospinal fluid barriers) throughout the brain and spinal cord suggests a role in water transport under normal and pathological conditions. Phenotype studies of transgenic mice lacking AQP4 have provided evidence for a role of AQP4 in cerebral water balance and neural signal transduction....
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