Article

Dissociation of SYNGAP1 Enzymatic and Structural Roles: Intrinsic Excitability and Seizure Susceptibility

2025-01-14

Abstract excerpt

SYNGAP1 is a key Ras-GAP protein enriched at excitatory synapses, with mutations causing intellectual disability and epilepsy in humans. Recent studies have revealed that in addition to its role as a negative regulator of G-protein signaling through its GAP enzymatic activity, SYNGAP1 plays an important structural role through its interaction with post-synaptic density proteins. Here, we reveal that intrinsic exci...

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Literature Corpus work: 8eb8f91a-ce6d-53fd-835d-1ddc7d4b1175
DOI: 10.1101/2025.01.14.633019

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