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Article

Greatly improved survival and neuroprotection in aquaporin‐4‐knockout mice following global cerebral ischemia

1 Nov 2013

Abstract excerpt

Aquaporin-4 (AQP4), the principal water channel in astrocytes, is involved in brain water movement, inflammation, and neuroexcitation. In this study, there was strong neuroprotection in mice lacking AQP4 in a model of global cerebral ischemia produced by transient, bilateral carotid artery occlusion (BCAO). Survival and neurological outcome were greatly improved in the AQP4(-/-) vs. AQP4(+/+) mice after...

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PMID: 24186965
DOI: 10.1096/fj.13-231274

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