Article
DNA repair capacity of lymphoblastoid cell lines from sisters discordant for breast cancer.
Journal of the National Cancer Institute - 19 Jan 2005
Kennedy David O, Agrawal Meenakshi, Shen Jing, Terry Mary Beth, Zhang Fang Fang, Senie Ruby T, Motykiewicz Grazyna, Santella Regina M
Abstract excerpt
BACKGROUND: Interindividual differences in DNA repair capacity may influence cancer risk. We tested whether the nucleotide excision repair pathway was deficient in breast cancer case patients by analyzing sister pairs. METHODS: Cell lines derived from sisters discordant for breast cancer (137 families containing 158 case patients and 154 control sisters) were obtained from the Metropolitan New York Registry of...
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