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Article

A sensitive test for the detection of specific DSB repair defects in primary cells from breast cancer specimens.

International journal of cancer - 1 Aug 2008

Keimling Marlen, Kaur Jatinder, Bagadi Sarangadhara Appala Raju, Kreienberg Rolf, Wiesmüller Lisa, Ralhan Ranju

Abstract excerpt

Increasing evidence indicates that breast cancer pathogenesis is linked with DNA double-strand break (DSB) repair dysfunction. This conclusion is based on advances in the study of functions of breast cancer susceptibility genes such as BRCA1 and BRCA2, on the identification of breast cancer-associated changes regarding the genetics, expression, and localization of multiple DSB repair factors, and on observations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18491400
DOI: 10.1002/ijc.23551

Genes

BRCA1
BRCA2
PARP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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