Article
p53 inactivation in chewing tobacco-induced oral cancers and leukoplakias from India.
Oral oncology - 1 May 1999
Saranath D, Tandle A T, Teni T R, Dedhia P M, Borges A M, Parikh D, Sanghavi V, Mehta A R
Abstract excerpt
The inactivation of p53 tumour suppressor gene vis-á-vis point mutation, overexpression and degradation due to Human Papilloma virus (HPV) 16/18 infection, was examined in chewing tobacco-associated oral cancers and oral leukoplakias from India. The analysis of mutations was assessed by polymerase chain reaction (PCR) with single strand conformation polymorphism (PCR-SSCP) of exons 5-9 on DNA from 83 oral cancer...
Topics
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Squamous Cell
- DNA, Neoplasm
- Female
- Genes, p53
- Humans
- India
- Leukoplakia, Oral
- Male
- Middle Aged
- Mouth Neoplasms
- Mutation
- Papillomaviridae
- Plants, Toxic
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational