Article
p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features.
Oncogene - 1 Jan 1992
Mitsudomi T, Steinberg S M, Nau M M, Carbone D, D'Amico D, Bodner S, Oie H K, Linnoila R I, Mulshine J L, Minna J D
Abstract excerpt
We screened 77 non-small-cell lung cancer (NSCLC) cell lines for mutations of the p53 gene using a single-strand conformation polymorphism (SSCP) assay. We found that 57 cell lines (74%) had mutations of the p53 gene. Three cell lines had a deletion of the p53 gene. Of the remaining 54 cell lines...
Topics
- Amino Acid Sequence
- Carcinoma, Non-Small-Cell Lung
- Exons
- Female
- Genes, p53
- Genes, ras
- Genetic Testing
- Humans
- Lung Neoplasms
- Male
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Tumor Cells, Cultured