Article
Characterization of Notch3-deficient mice: normal embryonic development and absence of genetic interactions with a Notch1 mutation.
Genesis (New York, N.Y. : 2000) - 1 Nov 2003
Krebs Luke T, Xue Yingzi, Norton Christine R, Sundberg John P, Beatus Paul, Lendahl Urban, Joutel Anne, Gridley Thomas
Abstract excerpt
The Notch signaling pathway is an evolutionarily conserved signaling mechanism and mutations in its components disrupt cell fate specification and embryonic development in many organisms. To analyze the in vivo role of the Notch3 gene in mice, we created a deletion allele by gene targeting. Embryos homozygous for this mutation developed normally and homozygous mutant adults were viable and fertile. We also...
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