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Article

Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo.

The Journal of cell biology - 30 Jul 2007

Geffers Insa, Serth Katrin, Chapman Gavin, Jaekel Robert, Schuster-Gossler Karin, Cordes Ralf, Sparrow Duncan B, Kremmer Elisabeth, Dunwoodie Sally L, Klein Thomas, Gossler Achim

Abstract excerpt

The Notch ligands Dll1 and Dll3 are coexpressed in the presomitic mesoderm of mouse embryos. Despite their coexpression, mutations in Dll1 and Dll3 cause strikingly different defects. To determine if there is any functional equivalence, we replaced Dll1 with Dll3 in mice. Dll3 does not compensate...

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Share to Body Patterning
Share to Calcium-Binding Proteins
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intercellular Signaling Peptides and Proteins

Share to Receptors, Notch

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Share to Wings, Animal

Source

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Identifiers

PMID: 17664336
DOI: 10.1083/jcb.200702009
PMCID: PMC2064846

Genes

DLL3
DLL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17664336-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo.PMID 17664336Read ↗

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