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Article

Targeted disruption of the mouse phospholipase C beta3 gene results in early embryonic lethality.

FEBS letters - 18 Dec 1998

Wang S, Gebre-Medhin S, Betsholtz C, Stålberg P, Zhou Y, Larsson C, Weber G, Feinstein R, Oberg K, Gobl A, Skogseid B

Abstract excerpt

In order to investigate the biological function of phosphatidylinositol-specific phospholipase C (PLC) we generated mutant mice by gene targeting. Homozygous inactivation of PLCbeta3 is lethal at embryonic day 2.5. These mutants show poor embryonic organization as well as reduced numbers of cells. Identical phenotypes were recorded in homozygous mutants generated from two independently targeted embryonic stem...

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PMID: 9883896
DOI: 10.1016/s0014-5793(98)01518-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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