Article
Targeted disruption of the mouse phospholipase C beta3 gene results in early embryonic lethality.
FEBS letters - 18 Dec 1998
Wang S, Gebre-Medhin S, Betsholtz C, Stålberg P, Zhou Y, Larsson C, Weber G, Feinstein R, Oberg K, Gobl A, Skogseid B
Abstract excerpt
In order to investigate the biological function of phosphatidylinositol-specific phospholipase C (PLC) we generated mutant mice by gene targeting. Homozygous inactivation of PLCbeta3 is lethal at embryonic day 2.5. These mutants show poor embryonic organization as well as reduced numbers of cells...
Topics
- Animals
- Cell Line
- Female
- Fetal Death
- Gene Targeting
- Genes, Lethal
- Heterozygote
- Humans
- Immunohistochemistry
- Isoenzymes
- Male
- Mice
- Mice, Mutant Strains
- Phenotype
- Phospholipase C beta
- Type C Phospholipases