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Article

Dkk1 and Wnt3 interact to control head morphogenesis in the mouse.

Development (Cambridge, England) - 1 May 2008

Lewis Samara L, Khoo Poh-Lynn, De Young R Andrea, Steiner Kirsten, Wilcock Chris, Mukhopadhyay Mahua, Westphal Heiner, Jamieson Robyn V, Robb Lorraine, Tam Patrick P L

Abstract excerpt

Loss of Dkk1 results in ectopic WNT/beta-catenin signalling activity in the anterior germ layer tissues and impairs cell movement in the endoderm of the mouse gastrula. The juxtaposition of the expression domains of Dkk1 and Wnt3 is suggestive of an antagonist-agonist interaction. The downregulation of Dkk1 when Wnt3 activity is reduced reveals a feedback mechanism for regulating WNT signalling. Compound...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18403408
DOI: 10.1242/dev.018853

Genes

WNT3
DKK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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