Article
Overview of genetic tools and techniques to study Notch signaling in mice.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2014
Gridley Thomas, Groves Andrew K
Abstract excerpt
Aberrations of Notch signaling in humans cause both congenital and acquired defects and cancers. Genetically engineered mice provide the most efficient and cost-effective models to study Notch signaling in a mammalian system. Here, we review the various types of genetic models, tools, and strategies to study Notch signaling in mice, and provide examples of their use. We also provide advice on breeding strategies...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.