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Article

Chimeric analysis of Notch2 function: a role for Notch2 in the development of the roof plate of the mouse brain.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Oct 2002

Kadokawa Yuzo, Marunouchi Tohru

Abstract excerpt

Notch proteins are transmembrane receptors involved in cell-fate determination throughout development. Targeted disruption of either the Notch1 or Notch2 gene in mice results in embryonic lethality around embryonic day (E) 10.5 with widespread cell death. Although Notch1-deficient mice show disorganized somitogenesis, Notch2 mutants did not show definitive abnormalities in any tissue expressing high levels of the...

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PMID: 12242712
DOI: 10.1002/dvdy.10140

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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