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Article

A knockout-first model of H3f3a gene targeting leads to developmental lethality.

Genesis (New York, N.Y. : 2000) - 1 Mar 2023

Bush Kelly, Cervantes Vanessa, Yee Jennifer Q, Klein Rachel H, Knoepfler Paul S

Abstract excerpt

Histone variant H3.3 is encoded by two genes, H3f3a and H3f3b, which can be expressed differentially depending on tissue type. Previous work in our lab has shown that knockout of H3f3b causes some neonatal lethality and infertility in mice, and chromosomal defects in mouse embryonic fibroblasts (MEFs). Studies of H3f3a and H3f3b null mice by others have produced generally similar phenotypes to what we found in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36656301
DOI: 10.1002/dvg.23507
PMCID: PMC10038898

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