Article
Knock-in mutation of transcription factor GATA-3 into the GATA-1 locus: partial rescue of GATA-1 loss of function in erythroid cells.
Developmental biology - 15 Apr 1998
Tsai F Y, Browne C P, Orkin S H
Abstract excerpt
Transcription factors of the GATA-family are essential for proper development of diverse tissues or cell types. GATA-1 is required for differentiation of two hematopoietic lineages (red blood cells and megakaryocytes), whereas GATA-3 is essential for T-cell development. Functional studies suggest that many properties of the GATA-family of proteins are shared and largely interchangeable. To test whether the...
Topics
- Anemia
- Animals
- Apoptosis
- Cell Line, Transformed
- DNA, Complementary
- DNA-Binding Proteins
- Embryonic and Fetal Development
- Erythroid Precursor Cells
- Erythroid-Specific DNA-Binding Factors
- Erythropoiesis
- Female
- Fetus
- GATA1 Transcription Factor
- GATA3 Transcription Factor