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Article

Generation and Characterization of <i>dickkopf3</i> Mutant Mice

1 Mar 2006

Abstract excerpt

dickkopf (dkk) genes encode a small family of secreted Wnt antagonists, except for dkk3, which is divergent and whose function is poorly understood. Here, we describe the generation and characterization of dkk3 mutant mice. dkk3-deficient mice are viable and fertile. Phenotypic analysis shows no major alterations in organ morphology, physiology, and most clinical chemistry parameters. Since Dkk3 was proposed to...

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PMID: 16508007
DOI: 10.1128/mcb.26.6.2317-2326.2006

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