Article
Regulation of Ku-DNA association by Yku70 C-terminal tail and SUMO modification.
The Journal of biological chemistry - 11 Apr 2014
Hang Lisa E, Lopez Christopher R, Liu Xianpeng, Williams Jaime M, Chung Inn, Wei Lei, Bertuch Alison A, Zhao Xiaolan
Abstract excerpt
The Ku70-Ku80 ring complex encloses DNA ends to facilitate telomere maintenance and DNA break repair. Many studies focus on the ring-forming regions of subunits Ku70 and Ku80. Less is known about the Ku70 C-terminal tail, which lies outside the ring. Our results suggest that this region is responsible for dynamic sumoylation of Yku70 upon DNA association in budding yeast. Mutating a cluster of five lysines in...
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