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Article

Investigation of polymorphism in the MDR1 gene and antidepressant-induced mania.

The pharmacogenomics journal - 1 Jan 2003

De Luca V, Mundo E, Trakalo J, Wong G W H, Kennedy J L

Abstract excerpt

The involvement of the multi-drug-resistant 1 P-glycoprotein gene (MDR1 P-gp) in the transport of antidepressants across the blood-brain barrier makes it a good candidate for the prediction of antidepressant response and side effects. We investigated the role of the MDR1 P-gp gene in predicting the induction of mania in bipolar patients (BP) treated with proserotonergic drugs. Participants met the DSM-IV criteria...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 14583799
DOI: 10.1038/sj.tpj.6500196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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