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Genetic and clinical characteristics associated with antidepressant-induced mania in depression patients.

Comprehensive psychiatry - 1 Jan 2026

Huang Shiau-Shian, Chao Ying-Ting, Chen Yu-Ning, Su Mei-Hsin, Chang Chiao-Erh, Tsai Shih-Jen, Kuo Po-Hsiu

Abstract excerpt

INTRODUCTION: Antidepressant-induced mania (AIM) is a significant clinical concern, primarily studied in bipolar disorder patients. Limited research exists on AIM in unipolar depression, with reported incidence rates of 3.0-8.2 %. METHODS: Using data from the Taiwan's National Health Insurance Research Database merged with Taiwan Biobank (2001-2017), we analyzed 772 depression patients who were prescribed...

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PMID: 41274093
DOI: 10.1016/j.comppsych.2025.152648

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