Article
The role of genetic variation of BDNF gene in antidepressant-induced mania in bipolar disorder.
Psychiatry research - 30 Nov 2010
de Aguiar Ferreira Alexandre, Neves Fernando Silva, Pimenta Guilherme José Garcia Santos, Mello Marina Pena, Miranda Débora Marques, Romano-Silva Marco Aurélio, De Marco Luiz Armando, Corrêa Humberto
Abstract excerpt
The occurrence of mania during antidepressant treatment is a key issue in the clinical management of bipolar disorder (BD). Brain-derived neurotrophic factor (BDNF) has been implicated in the pathogenesis of mood disorders. Moreover, antidepressants increase the expression of BDNF and its overactivity may be involved in the mechanism of development of the manic state. The aim of the present study was to test the...
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