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Article

Molecular basis of loss-of-function mutations in the glp-1 gene of Caenorhabditis elegans.

Molecular biology of the cell - 1 Nov 1992

Kodoyianni V, Maine E M, Kimble J

Abstract excerpt

The glp-1 gene encodes a membrane protein required for inductive cell interactions during development of the nematode Caenorhabditis elegans. Here we report the molecular characterization of 15 loss-of-function (lf) mutations of glp-1. Two nonsense mutations appear to eliminate glp-1 activity; bo...

Topics

Amino Acid Sequence
Animals
Ankyrins
Base Sequence
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cloning, Molecular
Epidermal Growth Factor
Genes, Helminth
Membrane Glycoproteins
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Receptors, Notch

Repetitive Sequences, Nucleic Acid

Restriction Mapping

Source

Open in PubMed Open full text

Identifiers

PMID: 1457827
DOI: 10.1091/mbc.3.11.1199
PMCID: PMC275687

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1457827-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Molecular basis of loss-of-function mutations in the glp-1 gene of Caenorhabditis elegans.PMID 1457827Read ↗

Intragenic dominant suppressors of glp-1, a gene essential for cell-signaling in Caenorhabditis elegans, support a role for cdc10/SWI6/ankyrin motifs in GLP-1 function.Semantic proximity Read ↗

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The Caenorhabditis elegans sel-1 gene, a negative regulator of lin-12 and glp-1, encodes a predicted extracellular protein.Semantic proximity Read ↗

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Genetic mutations in GLP-1/Notch pathway reveal distinct mechanisms of Notch signaling in germline stem cell regulationSemantic proximity Read ↗

Identification of residues of the Caenorhabditis elegans LIN-1 ETS domain that are necessary for DNA binding and regulation of vulval cell fates.Semantic proximity Read ↗

Suppressors of glp-1, a gene required for cell communication during development in Caenorhabditis elegans, define a set of interacting genes.Semantic proximity Read ↗

Control of cell fate in C. elegans by a GLP-1 peptide consisting primarily of ankyrin repeats.Semantic proximity Read ↗

Two homologous regulatory genes, lin-12 and glp-1, have overlapping functions.Semantic proximity Read ↗

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