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Article

Molecular basis of loss-of-function mutations in the glp-1 gene of Caenorhabditis elegans.

Molecular biology of the cell - 1 Nov 1992

Kodoyianni V, Maine E M, Kimble J

Abstract excerpt

The glp-1 gene encodes a membrane protein required for inductive cell interactions during development of the nematode Caenorhabditis elegans. Here we report the molecular characterization of 15 loss-of-function (lf) mutations of glp-1. Two nonsense mutations appear to eliminate glp-1 activity; both truncate the glp-1 protein in its extracellular domain and have a strong loss-of-function phenotype. Twelve missense...

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Identifiers

PMID: 1457827
DOI: 10.1091/mbc.3.11.1199
PMCID: PMC275687

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular basis of loss-of-function mutations in the glp-1 gene of Caenorhabditis elegans.PMID 1457827Read ↗

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