Article
Intragenic dominant suppressors of glp-1, a gene essential for cell-signaling in Caenorhabditis elegans, support a role for cdc10/SWI6/ankyrin motifs in GLP-1 function.
Genetics - 1 Dec 1993
Lissemore J L, Currie P D, Turk C M, Maine E M
Abstract excerpt
The glp-1 gene product mediates cell-cell interactions required for cell fate specification during development in Caenorhabditis elegans. To identify genes that interact with glp-1, we screened for dominant suppressors of two temperature-sensitive glp-1 alleles and recovered 18 mutations that suppress both germline and embryonic glp-1 phenotypes. These dominant suppressors are tightly linked to glp-1 and do not...
Topics
- Amino Acid Sequence
- Ankyrin Repeat
- Caenorhabditis elegans Proteins
- Cell Communication
- Gene Frequency
- Genes, Dominant
- Genes, Helminth
- Genes, Suppressor
- Helminth Proteins
- Membrane Glycoproteins
- Molecular Sequence Data
- Mutation
- Receptors, Notch