Article
The Caenorhabditis elegans sel-1 gene, a negative regulator of lin-12 and glp-1, encodes a predicted extracellular protein.
Genetics - 1 May 1996
Grant B, Greenwald I
Abstract excerpt
The Caenorhabditis elegans lin-12 and glp-1 genes encode members of the LIN-12/NOTCH family of receptors. The sel-1 gene was identified as an extragenic suppressor of a lin-12 hypomorphic mutant. We show in this report that the sel-1 null phenotype is wild type, except for an apparent elevation i...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cloning, Molecular
- DNA Primers
- Gene Expression Regulation
- Genes, Helminth
- Genes, Regulator
- Genotype
- Helminth Proteins
- Membrane Glycoproteins
- Membrane Proteins
- Models, Genetic
- Molecular Sequence Data
- Mutagenesis