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Article

Two homologous regulatory genes, lin-12 and glp-1, have overlapping functions.

Development (Cambridge, England) - 1 May 1991

Lambie E J, Kimble J

Abstract excerpt

Two homologous genes, lin-12 and glp-1, encode transmembrane proteins required for regulatory cell interactions during C. elegans development. Based on their single mutant phenotypes, each gene has been thought to govern a distinct set of cell fates. We show here that lin-12 and glp-1 are functionally redundant during embryogenesis: Unlike either single mutant, the lin-12 glp-1 double mutant dies soon after...

Topics

Animals
Caenorhabditis
Genes, Regulator
Membrane Proteins
Microscopy, Electron
Mutation
Phenotype
Sequence Homology, Nucleic Acid

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1769331
DOI: 10.1242/dev.112.1.231

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1769331-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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