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Article

Carboxy-terminal truncation activates glp-1 protein to specify vulval fates in Caenorhabditis elegans.

Nature - 29 Aug 1991

Mango S E, Maine E M, Kimble J

Abstract excerpt

The glp-1 and lin-12 genes encode homologous transmembrane proteins that may act as receptors for cell interactions during development. The glp-1 product is required for induction of germ-line proliferation and for embryogenesis. By contrast, lin-12 mediates somatic cell interactions, including those between the precursor cells that form the vulval hypodermis (VPCs). Here we analyse an unusual allele of glp-1,...

Topics

Amino Acid Sequence
Animals
Caenorhabditis
Caenorhabditis elegans Proteins
Cell Division
Female
Germ Cells
Membrane Glycoproteins
Membrane Proteins
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Receptors, Notch

Vulva

Source

Identifiers

PMID: 1881436
DOI: 10.1038/352811a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1881436-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Carboxy-terminal truncation activates glp-1 protein to specify vulval fates in Caenorhabditis elegans.PMID 1881436Read ↗

Suppressors of glp-1, a gene required for cell communication during development in Caenorhabditis elegans, define a set of interacting genes.Semantic proximity Read ↗

Intragenic dominant suppressors of glp-1, a gene essential for cell-signaling in Caenorhabditis elegans, support a role for cdc10/SWI6/ankyrin motifs in GLP-1 function.Semantic proximity Read ↗

Two homologous regulatory genes, lin-12 and glp-1, have overlapping functions.Semantic proximity Read ↗

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Germ-line tumor formation caused by activation of glp-1, a Caenorhabditis elegans member of the Notch family of receptors.Semantic proximity Read ↗

Genetic analysis of Caenorhabditis elegans glp-1 mutants suggests receptor interaction or competition.Semantic proximity Read ↗

Enhancers of glp-1, a gene required for cell-signaling in Caenorhabditis elegans, define a set of genes required for germline development.Semantic proximity Read ↗

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Genetic mutations in GLP-1/Notch pathway reveal distinct mechanisms of Notch signaling in germline stem cell regulation.Semantic proximity Read ↗

The <i>glp-1</i> 3ʹ untranslated region regulates germline proliferation and promotes reproductive fecundity through multiple mechanismsSemantic proximity Read ↗

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