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Article

Gain-of-function mutations in the Caenorhabditis elegans lin-1 ETS gene identify a C-terminal regulatory domain phosphorylated by ERK MAP kinase.

Genetics - 1 Aug 1998

Jacobs D, Beitel G J, Clark S G, Horvitz H R, Kornfeld K

Abstract excerpt

Genetic analysis of lin-1 loss-of-function mutations suggests that lin-1 controls multiple cell-fate decisions during Caenorhabditis elegans development and is negatively regulated by a conserved receptor tyrosine kinase-Ras-ERK mitogen-activated protein (MAP) kinase signal transduction pathway. LIN-1 protein contains an ETS domain and presumably regulates transcription. We identified and characterized six...

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Identifiers

PMID: 9691039
DOI: 10.1093/genetics/149.4.1809
PMCID: PMC1460263

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