Article
Spontaneous aberrant crypt foci in Apc1638N mice with a mutant Apc allele.
The American journal of pathology - 1 Nov 2003
Pretlow Theresa P, Edelmann Winfried, Kucherlapati Raju, Pretlow Thomas G, Augenlicht Leonard H
Abstract excerpt
The Apc1638N/+ mouse has a chain-terminating mutation in one allele of the adenomatous polyposis coli (Apc) gene that is similar to most mutations observed in the human familial adenomatous polyposis syndrome. Aberrant crypt foci (ACF), the earliest identified neoplastic lesions in the colon, are morphologically abnormal structures that are identifiedmicroscopically in the grossly normal colonic mucosas of...
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