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Identification of Mucin Depleted Foci in the Human Colon

1 Dec 2008

Abstract excerpt

Aberrant crypt foci (ACF) originally described in rodents treated with colon-specific carcinogens have been identified also in humans at high risk of colon cancer (CRC) and are extensively used as cancer biomarkers. However, studies documenting the heterogeneity of ACF have questioned their precancerous nature. Recently, we described dysplastic foci depleted of mucins (MDF) in the colon of rats treated with...

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PMID: 19139006
DOI: 10.1158/1940-6207.capr-08-0125

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