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Article

Study of the APC gene function in the mouse APC+/APC1638N model.

Neuro endocrinology letters - 1 Jan 2012

Adamcikova Zuzana, Wachsmannova Lenka, Hainova Katarina, Stevurkova Viola, Holec Vladimir, Ciernikova Sona, Cierna Zuzana, Janega Pavol, Babal Pavel, Mego Michal, Zajac Vladimir

Abstract excerpt

OBJECTIVES: Familial adenomatous polyposis (FAP) is an autosomal dominant disease characterized by the presence of hundreds to thousands of benign polyps in the colon. If not removed prophylactically they represent a risk of developing malignant cancer with an almost 100% penentrance. FAP is induced by germline mutation in the APC gene. Tumorigenesis launched a second somatic mutation of APC gene allele, leading...

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Identifiers

PMID: 22467108

Genes

APC
FAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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