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Article

Aberrant crypt foci as microscopic precursors of colorectal cancer.

World journal of gastroenterology - 1 Dec 2003

Cheng Lei, Lai Mao-De

Abstract excerpt

Since the first detection of aberrant crypt foci (ACF) in carcinogen-treated mice, there have been numerous studies focusing on these microscopically visible lesions both in rodents and in humans. ACF have been generally accepted as precancerous lesions in regard to histopathological characteristics, biochemical and immunohistochemical alterations, and genetic and epigenetic alterations. ACF show variable...

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Identifiers

PMID: 14669304
DOI: 10.3748/wjg.v9.i12.2642
PMCID: PMC4612023

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APC

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