Article
A mouse model of human familial adenomatous polyposis.
The Journal of experimental zoology - 15 Feb 1997
Yang K, Edelmann W, Fan K, Lau K, Kolli V R, Fodde R, Khan P M, Kucherlapati R, Lipkin M
Abstract excerpt
In an effort to generate a good mouse model for human colorectal cancer, we generated mice which carry a mutation in the adenomatous polyposis coli (Apc) gene. Mice which are heterozygous for the mutation, designated Apc1638, develop colonic polyps and tumors of the small intestine. Neoplasms were found in 96% of animals studied, and they included adenomas, adenocarcinomas, and polypoid hyperplasias. The mice...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.