Microsatellite instability in aberrant crypt foci from human colons.

Article

Microsatellite instability in aberrant crypt foci from human colons.

Cancer research - 1 Dec 1996

Heinen C D, Shivapurkar N, Tang Z, Groden J, Alabaster O

Abstract excerpt

Aberrant crypt foci (ACF) are distinct microscopic lesions of the colon thought to be the earliest identifiable precursors of colon cancer. As precursors of colon cancer, ACF may contain mutations in genes that are altered early in colorectal tumorigenesis. Candidates for these genes include APC,...

Topics

Colon
Colorectal Neoplasms
DNA
Humans
Intestinal Mucosa
Microsatellite Repeats
Phenotype
Precancerous Conditions

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