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Article

Understanding phenotypic variation in rodent models with germline Apc mutations.

Cancer research - 15 Apr 2013

Zeineldin Maged, Neufeld Kristi L

Abstract excerpt

Adenomatous polyposis coli (APC) is best known for its crucial role in colorectal cancer suppression. Rodent models with various Apc mutations have enabled experimental validation of different Apc functions in tumors and normal tissues. Since the development of the first mouse model with a germline Apc mutation in the early 1990s, 20 other Apc mouse and rat models have been generated. This article compares and...

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Source

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Identifiers

PMID: 23580574
DOI: 10.1158/0008-5472.CAN-12-4607
PMCID: PMC3630257

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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