Article
Altered Interactions between the Gut Microbiome and Colonic Mucosa Precede Polyposis in APCMin/+ Mice.
PloS one - 1 Jan 2015
Son Joshua S, Khair Shanawaj, Pettet Donald W, Ouyang Nengtai, Tian Xinyu, Zhang Yuanhao, Zhu Wei, Mackenzie Gerardo G, Robertson Charles E, Ir Diana, Frank Daniel N, Rigas Basil, Li Ellen
Abstract excerpt
Mutation of the adenomatous polyposis coli (APC gene), an early event in the adenoma-carcinoma sequence, is present in 70-80% of sporadic human colorectal adenomas and carcinomas. To test the hypothesis that mutation of the APC gene alters microbial interactions with host intestinal mucosa prior to the development of polyposis, culture-independent methods (targeted qPCR assays and Illumina sequencing of the 16S...
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