Article
More than two decades of Apc modeling in rodents.
Biochimica et biophysica acta - 1 Aug 2013
Zeineldin Maged, Neufeld Kristi L
Abstract excerpt
Mutation of tumor suppressor gene adenomatous polyposis coli (APC) is an initiating step in most colon cancers. This review summarizes Apc models in mice and rats, with particular concentration on those most recently developed, phenotypic variation among different models, and genotype/phenotype correlations.
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