Article
Transmission of murine scrapie to P101L transgenic mice.
The Journal of general virology - 1 Nov 2003
Barron Rona M, Thomson Val, King Declan, Shaw Jane, Melton David W, Manson Jean C
Abstract excerpt
The PrP protein is central to the transmissible spongiform encephalopathies (TSEs), and the amino acid sequence of this protein in the host can influence both incubation time of disease and targeting of disease pathology. The N terminus of murine PrP has been proposed to be important in the replication of TSE agents, as mutations or deletions in that region can alter the efficiency of agent replication. To...
Topics
- Animals
- Brain
- Mice
- Mice, Transgenic
- Mutation
- Prions
- Scrapie
- Structure-Activity Relationship
- Time Factors
- Vacuoles