Article
Serial transmission in rodents of neurodegeneration from transgenic mice expressing mutant prion protein.
Proceedings of the National Academy of Sciences of the United States of America - 13 Sept 1994
Hsiao K K, Groth D, Scott M, Yang S L, Serban H, Rapp D, Foster D, Torchia M, Dearmond S J, Prusiner S B
Abstract excerpt
Two lines of transgenic (Tg) mice expressing high (H) levels of the mutant P101L prion protein (PrP) developed a neurologic illness and central nervous system pathology indistinguishable from experimental murine scrapie; these mice were designated Tg(MoPrP-P101L)H. Brain homogenates from Tg(MoPrP...
Topics
- Animals
- Cricetinae
- Gerstmann-Straussler-Scheinker Disease
- Mesocricetus
- Mice
- Mice, Transgenic
- Mutation
- PrPSc Proteins
- Prions
- Scrapie