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Article

Strain specific resistance to murine scrapie associated with a naturally occurring human prion protein polymorphism at residue 171.

PLoS pathogens - 1 Sept 2011

Striebel James F, Race Brent, Meade-White Kimberly D, LaCasse Rachel, Chesebro Bruce

Abstract excerpt

Transmissible spongiform encephalopathies (TSE) or prion diseases are neurodegenerative disorders associated with conversion of normal host prion protein (PrP) to a misfolded, protease-resistant form (PrPres). Genetic variations of prion protein in humans and animals can alter susceptibility to both familial and infectious prion diseases. The N171S PrP polymorphism is found mainly in humans of African descent,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21980292
DOI: 10.1371/journal.ppat.1002275
PMCID: PMC3182929

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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