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Article

Human prion strain selection in transgenic mice.

Annals of neurology - 1 Aug 2010

Giles Kurt, Glidden David V, Patel Smita, Korth Carsten, Groth Darlene, Lemus Azucena, DeArmond Stephen J, Prusiner Stanley B

Abstract excerpt

OBJECTIVE: Transgenic (Tg) mice expressing chimeras of mouse and human prion proteins (PrPs) have shorter incubation periods for Creutzfeldt-Jakob disease (CJD) prions than mice expressing full-length human PrP. Increasing the sequence similarity of the chimeric PrP to mouse PrP, by reverting human residues to mouse, resulted in a Tg line, denoted Tg22372, which was susceptible to sporadic (s) CJD prions in...

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Source

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Identifiers

PMID: 20695008
DOI: 10.1002/ana.22104
PMCID: PMC2935907

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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