Article
Marked influence of the route of infection on prion strain apparent phenotype in a scrapie transgenic mouse model.
Neurobiology of disease - 1 Jan 2011
Langevin Christelle, Andréoletti Olivier, Le Dur Annick, Laude Hubert, Béringue Vincent
Abstract excerpt
Prion strains yield specific neuropathological features including spongiform degeneration and deposition patterns of pathological prion protein. Their invariant regional distribution, following variations in the infection route, has led to the proposal that prions replicate preferentially in defined neuro-anatomical areas. The molecular mechanisms underlying this apparent strain-specific neuronal tropism are...
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