Article
Interactions between wild-type and mutant prion proteins modulate neurodegeneration in transgenic mice.
Genes & development - 15 Jul 1996
Telling G C, Haga T, Torchia M, Tremblay P, DeArmond S J, Prusiner S B
Abstract excerpt
Transgenic mice overexpressing approximately eightfold the mouse (Mo) prion protein (PrP) gene carrying the P102L mutation of GSS developed neurodegeneration between 150 and 300 days of age, while controls expressing the wild-type MoPrP-A transgene at the same level remained healthy. Mice overexp...
Topics
- Animals
- Disease Models, Animal
- Female
- Gerstmann-Straussler-Scheinker Disease
- Humans
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Nerve Degeneration
- Phenotype
- Point Mutation
- Prion Diseases
- Prions