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Article

Sample size needed to detect gene-gene interactions using linkage analysis.

Annals of human genetics - 1 Nov 2007

Wang Shuang, Zhao Hongyu

Abstract excerpt

Gene-gene interactions have received much attention recently because most human traits may be under the control of several genetic factors, as well as environmental factors, and these factors likely interact among each other to influence these traits. Gauderman (2002) and Wang & Zhao (2003) have reported systematic studies on the statistical power to detect gene-gene interactions through association studies. In...

Topics

Female
Genetic Linkage
Humans
Likelihood Functions
Logistic Models
Male
Models, Genetic
Penetrance
Phenotype
Sample Size
Siblings

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Identifiers

PMID: 17521308
DOI: 10.1111/j.1469-1809.2007.00367.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17521308-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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