Sib-pair linkage tests for disease susceptibility loci: common tests vs. the asymptotically most powerful test.

doi:10.1002/gepi.1370070506

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Article

Sib-pair linkage tests for disease susceptibility loci: common tests vs. the asymptotically most powerful test.

Genetic epidemiology - 1 Jan 1990

Schaid D J, Nick T G

Abstract excerpt

Several statistical tests for linkage between a disease susceptibility locus and a marker locus for sib-pair data are examined analytically. Two common statistics, a test based on the mean number of marker alleles shared identical by descent by sib-pairs, and a test based on the proportion of sib...

Topics

Alleles
Genetic Predisposition to Disease
Humans
Mathematics
Models, Genetic
Models, Statistical

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