Article
Functional and molecular characterization of the epithelioid to round transition in human colorectal cancer LoVo cells.
Oncogene - 16 Oct 2003
Debruyne Philip R, Vermeulen Stefan J, Berx Geert, Pocard Marc, Correia da Rocha Ana-Sofia, Li Xuedong, Cirnes Luis, Poupon Marie-France, van Roy Frans M, Mareel Marc M
Abstract excerpt
In subclones of the human colon cancer LoVo cell line, there is a reproducible spontaneous transition from an epithelioid (E) to a round (R) morphotype. The E to R transition is associated with increased cell growth, absence of E-cadherin-dependent compaction in a slow aggregation assay, loss of contact inhibition of motility and directional migration in a wound filling motility assay. Furthermore, none of the E...
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